11/20/17 - Annual Reviews Immunology 2018 issue to include article from Yu Matsuzawa

Congratulations to Yu Matsuzawa and our co-author Seungmin Hwang at University of Chicago (http://shwanglab.bsd.uchicago.edu/) for having their paper accepted to Annu Rev Immunol! This article represents a comprehensive review of the literature concerning the role of autophagy and related processes in inflammation. The full article will become available on the journal website soon. The abstract and citation information are below:

Annu Rev Immunol. 2017 Nov 16. doi: 10.1146/annurev-immunol-042617-053253. Autophagy and Inflammation. Matsuzawa-Ishimoto Y, Hwang S, Cadwell K.


The cellular degradative pathway of autophagy has a fundamental role in immunity. Here, we review the function of autophagy and autophagy proteins in inflammation. We discuss how the autophagy machinery controls the burden of infectious agents while simultaneously limiting inflammatory pathologies, which often involves processes that are distinct from conventional autophagy. Among the newly emerging processes we describe are LC3-associated phagocytosis and targeting by autophagy proteins, both of which require many of the same proteins that mediate conventional autophagy. We also discuss how autophagy contributes to differentiation of myeloid and lymphoid cell types, coordinates multicellular immunity, and facilitates memory responses. Together, these functions establish an intimate link between autophagy, mucosal immunity, and chronic inflammatory diseases. Finally, we offer our perspective on current challenges and barriers to translation.

Expected final online publication date for the Annual Review of Immunology Volume 36 is April 26, 2018.