Axelrad JE, Cadwell K, Colombel JF, Shah SC. Therap Adv Gastroenterol. The role of gastrointestinal pathogens in inflammatory bowel disease: a systematic review. 2021 Mar 31;14:17562848211004493. PMID: 33868457

Venzon M, Bernard L, Klein J, Axelrad JE, Hussey GA, Sullivan AP, Casanovas-Massana A, Noval MG, Valero-Jimenez AM, Gago J, Wilder E, Yale IMPACT Research Team, Thorpe LE, Littman DR, Dittmann M, Stapleford KA, Shopsin B, Torres VJ, Ko AI, Iwasaki A, Cadwell K*, Schluter J*. Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation. bioRxiv 2021.07.15.452246

Jang K, Kaczmarek ME, Dallari S, Chen Y, Axelrad J, Stapleford KA*, Cadwell K*. Intestinal organoids expose heterogeneity in SARS-CoV-2 susceptibility. bioRxiv 2021.07.16.452680

Wong SY, Dixon R, Pazos VM, Gnjatic S, Colombel JF, Cadwell K. ICARUS-IBD Working Group. Serological response to mRNA COVID-19 vaccines in IBD patients receiving biological therapies. Gastroenterology. 2021 Aug;161(2):715-718.e4. PMC8055494

Dallari S, Heaney T, Rosas-Villegas A, Neil JA, SY, Brown JJ, Urbanek K, Herrmann C, Depledge DP, Dermody TS, Cadwell K. Enteric viruses evoke broad host immune responses resembling bacterial microbiome. Cell Host & Microbe. 2021 Jun 9;29(6):1014-1029. PMC8192460

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Klionsky et al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751

Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine. Yu S, Balasubramanian I, Laubitz D, Tong K, Bandyopadhyay S, Lin X, Flores J, Singh R, Liu Y, Macazana C, Zhao Y, Béguet-Crespel F, Patil K, Midura-Kiela MT, Wang D, Yap GS, Ferraris RP, Wei Z, Bonder EM, Häggblom MM, Zhang L, Douard V, Verzi MP, Cadwell K, Kiela PR, Gao N. Immunity. 2020 Aug 18;53(2):398-416.e8. PMID: 32814028

Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases. Iliev ID*, Cadwell K*. Gastroenterology. Mar;160(4):1050-1066. doi: 10.1053/j.gastro.2020.06.100. PMID: 33347881

Single Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells from Ulcerative Colitis Patients. Devlin JC, Axelrad J, Hine AM, Chang S, Sarkar S, Lin JD, Ruggles KV, Hudesman D, Cadwell K*, Loke P*. Gastroenterology. 2021 Apr;160(5):1679-1693. doi: 10.1053/j.gastro.2020.12.030. PMID: 33359089

Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells. Maisonneuve C, Tsang DKL, Foerster EG, Robert LM, Mukherjee T, Prescott D, Tattoli I, Lemire P, Winer DA, Winer S, Streutker CJ, Geddes K, Cadwell K, Ferrero RL, Martin A, Girardin SE, Philpott DJ. Cell Rep. 2021 Jan 26;34(4):108677. doi: 10.1016/j.celrep.2020.108677. PMID: 33503439

Mapping the evolutionary landscape of Zika virus infection in immunocompromised mice. Johnson KEE, Noval MG, Rangel MV, De Jesus E, Geber A, Schuster S, Cadwell K, Ghedin E, Stapleford KA. Virus Evol. 2020 Dec 11;6(2):veaa092. PMID: 33408879

Systematic review: gastrointestinal infection and incident inflammatory bowel disease. Axelrad JE, Cadwell KH, Colombel JF, Shah SC. Aliment Pharmacol Ther. 2020 Jun;51(12):1222-1232. doi: 10.1111/apt.15770. Epub 2020 May 5. PMID: 32372471 

An Intestinal Organoid-Based Platform That Recreates Susceptibility to T Cell-Mediated Tissue Injury. Matsuzawa-Ishimoto Y, Hine A, Shono Y, Rudensky E, Lazrak A, Yeung F, Neil JA, Yao X, Chen YH, Heaney T, Schuster SL, Zwack EE, Axelrad JE, Hudesman D, Tsai JJ, Nichols KB, Dewan MZ, Cammer M, Beal A, Hoffman S, Geddes B, Bertin J, Liu C, Torres VJ, Loke P, van den Brink MR, Cadwell K. Blood. 2020 Mar 30:blood.2019004116. doi: 10.1182/blood.2019004116. PMID: 32232483

Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization. Yeung F, Chen YH, Lin JD, Leung JM, McCauley C, Devlin JC, Hansen C, Cronkite A, Stephens Z, Drake-Dunn C, Fulmer Y, Shopsin B, Ruggles KV, Round JL, Loke P, Graham AL, Cadwell K. Cell Host Microbe. 2020 May 13;27(5):809-822.e6. doi: 10.1016/j.chom.2020.02.015. Epub 2020 Mar 24. PMID: 32209432

Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition. Lin JD, Devlin JC, Yeung F, McCauley C, Leung JM, Chen YH, Cronkite A, Hansen C, Drake-Dunn C, Ruggles KV, Cadwell K, Graham AL, Loke P. Cell Host Microbe. 2020 May 13;27(5):830-840.e4. doi: 10.1016/j.chom.2020.03.001. Epub 2020 Mar 24. PMID: 32209431

Decoy exosomes provide protection against bacterial toxins. Keller, Matthew D., Krystal L. Ching, Feng-Xia Liang, Avantika Dhabaria, Kayan Tam, Beatrix M. Ueberheide, Derya Unutmaz, Victor J. Torres, and Ken Cadwell. Nature. 2020 Mar 4. doi: 10.1038/s41586-020-2066-6. PMID: 32132711

Tumor Necrosis Factor-α-Induced Apoptosis in the Intestinal Epithelium due to Chronic Nuclear Factor Kappa B Signaling Is Mediated by Receptor Interacting Serine/Threonine Kinase 1. Yao X, Cadwell K. Cell Mol Gastroenterol Hepatol. 2019 Nov 16. pii: S2352-345X(19)30145-6. doi: 10.1016/j.jcmgh.2019.10.009. [Epub ahead of print] No abstract available. PMID: 31743657

Universal Principled Review: A Community-Driven Method to Improve Peer Review. Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M; Future Immunology Consortium. Cell. 2019 Dec 12;179(7):1441-1445. doi: 10.1016/j.cell.2019.11.029. PMID: 31835023

Autophagy and microbial pathogenesis. Keller MD, Torres VJ, Cadwell K. Cell Death Differ. 2020 Jan 2. doi: 10.1038/s41418-019-0481-8. [Epub ahead of print] Review. PMID: 31896796

Reinvigorating NIH Grant Peer Review. Crotty S, Blish C, Cadwell K, Chi H, Goldrath A, Green D, Kaech SM, Krummel M, Pepper M, Rothlin CV, Wherry EJ; Once-a-Year Pledge Supporters. Immunity. 2020 Jan 14;52(1):1-3. doi: 10.1016/j.immuni.2019.12.016. PMID: 31940266

Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. Xie Y, Zhao Y, Shi L, Li W, Chen K, Li M, Chen X, Zhang H, Li T, Yu MI, Yao X, Shao D, Ke Z, Li J, Chen Y, Zhang X, Cui J, Cui S, Leng Q, Cadwell K, Li X, Wei H, Zhang H, Li H, Xiao H. J Clin Invest. 2020 Jan 21. pii: 133264. doi: 10.1172/JCI133264. [Epub ahead of print] PMID: 31961824

IFN-I and IL-22 mediate protective effects of intestinal viral infection. Neil JA, Matsuzawa-Ishimoto Y, Kernbauer-Hölzl E, Schuster SL, Sota S, Venzon M, Dallari S, Galvao Neto A, Hine A, Hudesman D, Loke P, Nice TJ, Cadwell K. Nat Microbiol. 2019 Jun 10.PMID:31182797

Regulation of interferon signaling in response to gut microbes by autophagy. Martin PK, Cadwell K. Gut Microbes. 2019 May 23:1-9. PMID:31119977

Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice. Lubkin A, Lee WL, Alonzo F 3rd, Wang C, Aligo J, Keller M, Girgis NM, Reyes-Robles T, Chan R, O'Malley A, Buckley P, Vozhilla N, Vasquez MT, Su J, Sugiyama M, Yeung ST, Coffre M, Bajwa S, Chen E, Martin P, Kim SY, Loomis C, Worthen GS, Shopsin B, Khanna KM, Weinstock D, Lynch AS, Koralov SB, Loke P, Cadwell K, Torres VJ. Cell Host Microbe. 2019 Mar 13;25(3):463-470.e9. PMID:30799265

Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges. Hernandez Moura Silva, André Báfica, Gabriela Flavia Rodrigues-Luiz, Jingyi Chi, Patricia d’Emery Alves Santos, Bernardo S. Reis, David P. Hoytema van Konijnenburg, Audrey Crane, Raquel Duque Nascimento Arifa, Patricia Martin, Daniel Augusto G.B. Mendes, Daniel Santos Mansur, Victor J. Torres, Ken Cadwell, Paul Cohen, Daniel Mucida, Juan J. Lafaille. J Exp Med. 2019 Apr 1; 216(4): 786–806. PMID:30862706

Sugar Turns Bacteria Sweet: A Peace Offering in the Gut. Cadwell K. Cell. 2018 Sep 20;175(1):36-37. PMID:30241612

There was collusion: Microbes in inflammatory bowel disease.  Wong SY, Cadwell K. PLoS Pathog. 2018 Sep 20;14(9):e1007215. PMID:30235350

Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota.  Martin PK, Marchiando A, Xu R, Rudensky E, Yeung F, Schuster SL, Kernbauer E, Cadwell K. Nat Microbiol. 2018 Sep 10. PMID:30202015

The Intestinal Virome and Immunity. Neil JA, Cadwell K. J Immunol. 2018 Sep 15;201(6):1615-1624. PMID:30181300

B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains. Wong SY, Coffre M, Ramanan D, Hines MJ, Gomez LE, Peters LA, Schadt EE, Koralov SB, Cadwell K. J Immunol. 2018 Sep 1;201(5):1442-1451. PMID:30012848

Enteric Infections Are Common in Patients with Flares of Inflammatory Bowel Disease.  Axelrad JE, Joelson A, Green PHR, Lawlor G, Lichtiger S, Cadwell K, Lebwohl B. Am J Gastroenterol. 2018 Aug 3. PMID:30072777

Getting a Taste for Parasites in the Gut.  Loke P, Cadwell K. Immunity. 2018 Jul 17;49(1):16-18. PMID:30021142

Gut colonization with vancomycin-resistant Enterococcus and risk for subsequent enteric infection. Axelrad JE, Lebwohl B, Cuaresma E, Cadwell K, Green PHR, Freedberg DE. Gut Pathog. 2018 Jul 9;10:28. PMID:30002733

A20 and ABIN-1 team up against intestinal epithelial cell death. Cadwell K. J Exp Med. 2018 Jul 2;215(7):1771-1773. PMC6028507

Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr., McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW. Science. 2018 Apr 13;360(6385):204-208.

Myeloid ATG16L1 does not affect adipose tissue inflammation or body mass in mice fed high fat diet. Litwinoff EMS, Gold MY, Singh K, Hu J, Li H, Cadwell K, Schmidt AM. Obes Res Clin Pract. 2017 Nov 2. pii: S1871-403X(17)30118-7. PMC5932285

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. Cadwell K, Debnath J. J Cell Biol. 2017 Dec 13. pii: jcb.201706157. doi: 10.1083/jcb.201706157. PMC5839790

Matsuzawa-Ishimoto Y, Hwang S, Cadwell K. Autophagy and Inflammation. Annu Rev Immunol. 2017 Nov 16. doi: 10.1146/annurev-immunol-042617-053253.

Matsuzawa-Ishimoto Y, Shono Y, Gomez LE, Hubbard-Lucey VM, Cammer M, Neil J, Dewan MZ, Lieberman SR, Lazrak A, Marinis JM, Beal A, Harris PA, Bertin J, Liu C, Ding Y, van den Brink MRM, Cadwell K. Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium. J Exp Med. 2017 Dec 4;214(12):3687-3705. PMC5716041

Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P. Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. J Clin Invest. 2017 Jun 30;127(7):2789-2804. PMC5490766

Livanos AE, Greiner TU, Vangay P, Pathmasiri W, Stewart D, McRitchie S, Li H, Chung J, Sohn J, Kim S, Gao Z, Barber C, Kim J, Ng S, Rogers AB, Sumner S, Zhang XS, Cadwell K, Knights D, Alekseyenko A, Bäckhed F, Blaser MJ. Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Nat Microbiol. 2016 Aug 22;1(11):16140. PMC5593929

Cadwell K. Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis. Nat Rev Immunol. 2016 Nov;16(11):661-675. SharedIt Link:

Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y, Honda K, Gause WC, Blaser MJ, Bonneau RA, Lim YA, Loke P, Cadwell K. Helminth Infection Promotes Colonization Resistance via Type 2 Immunity. Science. 2016 Apr 14. 2016 Apr 29;352(6285):608-12. PMC4905769

Ramanan D, Cadwell K. Intrinsic Defense Mechanisms of the intestinal epithelium. Cell Host Microbe. 2016 Apr 13;19(4):434-441.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.

Sakowski ET, Koster S, Portal Celhay C, Park HS, Shrestha E, Hetzenecker SE, Maurer K, Cadwell K, Philips JA. Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis. PLoS Pathog. 2015 Jul 30;11(7):e1005076. PMID: 26225865

Maurer K, Torres VJ, Cadwell K. Autophagy is a key tolerance mechanism during Staphylococcus aureus infection. Autophagy. 2015 Jul 3;11(7):1184-6. PMID: 26046478

Cadwell K. The Virome in Host Health and Disease. Immunity. 2015 May 19;42(5):805-813. PMID: 25992857

Maurer K, Reyes-Robles T, Alonzo F, Durbin J, Torres VJ, Cadwell K. Autophagy Mediates Tolerance to Staphylococcus aureus Alpha-Toxin. Cell Host & Microbe. 2015 Apr 8;17(4):429-40. PMID: 25816775

Cadwell K. Expanding the role of the virome: commensalism in the gut. J Virol. 2015 Feb;89(4):1951-3. PMID: 25505079

Kernbauer E, Ding Y, Cadwell K. An enteric virus can replace the beneficial function of commensal bacteria. Nature. 2014 Dec 4;516(7529):94-8. PMID: 25409145

Kernbauer E, Maurer K, Torres V, Shopsin B, Cadwell K. Gastrointestinal dissemination and transmission of Staphylococcus aureus following bactermia. Infection and Immunity. 2015 Jan;83(1):372-8. PMID: 25385792

Hubbard-Lucey VM, Shono Y, Maurer K, West ML, Singer NV, Ziegler CGK, Lezcano C, Motta ACF, Schmid K, Levi SM, Murphy GF, Liu C, Winkler JD, Amaravadi RK, Rogler G, Dickinson AM, Holler E, van den Brink MRM, Cadwell K. Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells. Immunity. Oct 16;41(4):579-91. PMID: 25308334

Kernbauer E, Cadwell K. Autophagy, viruses, and intestinal immunity. Curr Op Gastroenterol. 2014 Nov;30(6):539-46. PMID: 25291356

Nod2 prevents small intestinal inflammation by restricting the expansion of a common member of the microbiota. Ramanan D, Bowcutt R, Tang MS, Loke P, Cadwell K. Immunity. 2014 Aug 21;41(2):311-24. PMID: 25088769

Bacteria, it's what's for dinner. Cadwell K. Cell Host Microbe. 2013 Jun 12;13(6):627-8. PMID: 23768486

Autophagy meets phagocytosis. Cadwell K, Philips JA. Immunity. 2013 Sep 19;39(3):425-7. PMID: 24054324

A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. Marchiando AM, Ramanan D, Ding Y, Gomez LE, Hubbard-Lucey VM, Maurer K, Wang C, Ziel JW, van Rooijen N, Nuñez G, Finlay BB, Mysorekar IU, Cadwell K. Cell Host Microbe. 2013 Aug 14;14(2):216-24. PMID: 23954160

FIP200 regulates targeting of Atg16L1 to the isolation membrane. Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, Mizushima N. EMBO Rep. 2013 Mar 1;14(3):284-91. PMID: 23392225

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS. EMBO J. 2013 Dec 11;32(24):3130-44. PMID: 24185898

Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ et al. Autophagy. 2012 Apr;8(4):445-544. PMID: 22966490

Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo. Wang C, Mendonsa GR, Symington JW, Zhang Q, Cadwell K, Virgin HW, Mysorekar IU. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):11008-13. PMID: 22715292

Viruses, autophagy genes, and Crohn's disease. Hubbard VM, Cadwell K. Viruses. 2011 Jul;3(7):1281-311. Review. PMID: 21994779

Crohn's disease susceptibility gene interactions, a NOD to the newcomer ATG16L1. Cadwell K. Gastroenterology. 2010 Nov;139(5):1448-50. PMID: 20875485

A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. Cadwell K, Patel KK, Komatsu M, Virgin HW 4th, Stappenbeck TS. Autophagy. 2009 Feb;5(2):250-2. PMID: 19139628

Role of autophagy and autophagy genes in inflammatory bowel disease. Cadwell K, Stappenbeck TS, Virgin HW. Curr Top Microbiol Immunol. 2009;335:141-67. Review. PMID: 19802564

Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Ju JS, Miller SE, Jackson E, Cadwell K, Piwnica-Worms D, Weihl CC. Autophagy. 2009 May;5(4):511-9. PMID: 19305149

Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, Mizushima NN, Xavier R, Virgin HW, Swat W. Autophagy. 2009 Jul;5(5):625-35. PMID: 19276668

The specificities of Kaposi's sarcoma-associated herpesvirus-encoded E3 ubiquitin ligases are determined by the positions of lysine or cysteine residues within the intracytoplasmic domains of their targets. Cadwell K, Coscoy L. J Virol. 2008 Apr;82(8):4184-9. PMID: 18272573

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th. Nature. 2008 Nov 13;456(7219):259-63. PMID: 18849966

The autophagy gene ATG5 plays an essential role in B lymphocyte development.  Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW 4th. Autophagy. 2008 Apr;4(3):309-14. PMID: 18188005

Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado MA, Ponpuak M, Green KG, Schmidt RE, Mizushima N, Deretic V, Sibley LD, Virgin HW. Cell Host Microbe. 2008 Nov 13;4(5):458-69. PMID: 18996346

Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase. Cadwell K, Coscoy L.  Science. 2005 Jul 1;309(5731):127-30. PMID: 15994556