Publications

Livanos AE, Greiner TU, Vangay P, Pathmasiri W, Stewart D, McRitchie S, Li H, Chung J, Sohn J, Kim S, Gao Z, Barber C, Kim J, Ng S, Rogers AB, Sumner S, Zhang XS, Cadwell K, Knights D, Alekseyenko A, Bäckhed F, Blaser MJ. Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Nat Microbiol. 2016 Aug 22;1(11):16140.

Cadwell K. Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis. Nat Rev Immunol. 2016 Nov;16(11):661-675.

Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y, Honda K, Gause WC, Blaser MJ, Bonneau RA, Lim YA, Loke P, Cadwell K. Helminth Infection Promotes Colonization Resistance via Type 2 Immunity. Science. 2016 Apr 14. 2016 Apr 29;352(6285):608-12. PMCID in process

Ramanan D, Cadwell K. Intrinsic Defense Mechanisms of the intestinal epithelium. Cell Host Microbe. 2016 Apr 13;19(4):434-441.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.

Sakowski ET, Koster S, Portal Celhay C, Park HS, Shrestha E, Hetzenecker SE, Maurer K, Cadwell K, Philips JA. Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis. PLoS Pathog. 2015 Jul 30;11(7):e1005076. PMID: 26225865

Maurer K, Torres VJ, Cadwell K. Autophagy is a key tolerance mechanism during Staphylococcus aureus infection. Autophagy. 2015 Jul 3;11(7):1184-6. PMID: 26046478

Cadwell K. The Virome in Host Health and Disease. Immunity. 2015 May 19;42(5):805-813. PMID: 25992857

Maurer K, Reyes-Robles T, Alonzo F, Durbin J, Torres VJ, Cadwell K. Autophagy Mediates Tolerance to Staphylococcus aureus Alpha-Toxin. Cell Host & Microbe. 2015 Apr 8;17(4):429-40. PMID: 25816775

Cadwell K. Expanding the role of the virome: commensalism in the gut. J Virol. 2015 Feb;89(4):1951-3. PMID: 25505079

Kernbauer E, Ding Y, Cadwell K. An enteric virus can replace the beneficial function of commensal bacteria. Nature. 2014 Dec 4;516(7529):94-8. PMID: 25409145

Kernbauer E, Maurer K, Torres V, Shopsin B, Cadwell K. Gastrointestinal dissemination and transmission of Staphylococcus aureus following bactermia. Infection and Immunity. 2015 Jan;83(1):372-8. PMID: 25385792

Hubbard-Lucey VM, Shono Y, Maurer K, West ML, Singer NV, Ziegler CGK, Lezcano C, Motta ACF, Schmid K, Levi SM, Murphy GF, Liu C, Winkler JD, Amaravadi RK, Rogler G, Dickinson AM, Holler E, van den Brink MRM, Cadwell K. Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells. Immunity. Oct 16;41(4):579-91. PMID: 25308334

Kernbauer E, Cadwell K. Autophagy, viruses, and intestinal immunity. Curr Op Gastroenterol. 2014 Nov;30(6):539-46. PMID: 25291356

Nod2 prevents small intestinal inflammation by restricting the expansion of a common member of the microbiota. Ramanan D, Bowcutt R, Tang MS, Loke P, Cadwell K. Immunity. 2014 Aug 21;41(2):311-24. PMID: 25088769

Bacteria, it's what's for dinner. Cadwell K. Cell Host Microbe. 2013 Jun 12;13(6):627-8. PMID: 23768486

Autophagy meets phagocytosis. Cadwell K, Philips JA. Immunity. 2013 Sep 19;39(3):425-7. PMID: 24054324

A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. Marchiando AM, Ramanan D, Ding Y, Gomez LE, Hubbard-Lucey VM, Maurer K, Wang C, Ziel JW, van Rooijen N, Nuñez G, Finlay BB, Mysorekar IU, Cadwell K. Cell Host Microbe. 2013 Aug 14;14(2):216-24. PMID: 23954160

FIP200 regulates targeting of Atg16L1 to the isolation membrane. Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, Mizushima N. EMBO Rep. 2013 Mar 1;14(3):284-91. PMID: 23392225

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS. EMBO J. 2013 Dec 11;32(24):3130-44. PMID: 24185898

Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ et al. Autophagy. 2012 Apr;8(4):445-544. PMID: 22966490

Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo. Wang C, Mendonsa GR, Symington JW, Zhang Q, Cadwell K, Virgin HW, Mysorekar IU. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):11008-13. PMID: 22715292

Viruses, autophagy genes, and Crohn's disease. Hubbard VM, Cadwell K. Viruses. 2011 Jul;3(7):1281-311. Review. PMID: 21994779

Crohn's disease susceptibility gene interactions, a NOD to the newcomer ATG16L1. Cadwell K. Gastroenterology. 2010 Nov;139(5):1448-50. PMID: 20875485

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW. Cell. 2010 Jun 25;141(7):1135-45. PMID: 20602997

A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. Cadwell K, Patel KK, Komatsu M, Virgin HW 4th, Stappenbeck TS. Autophagy. 2009 Feb;5(2):250-2. PMID: 19139628

Role of autophagy and autophagy genes in inflammatory bowel disease. Cadwell K, Stappenbeck TS, Virgin HW. Curr Top Microbiol Immunol. 2009;335:141-67. Review. PMID: 19802564

Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Ju JS, Miller SE, Jackson E, Cadwell K, Piwnica-Worms D, Weihl CC. Autophagy. 2009 May;5(4):511-9. PMID: 19305149

Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, Mizushima NN, Xavier R, Virgin HW, Swat W. Autophagy. 2009 Jul;5(5):625-35. PMID: 19276668

The specificities of Kaposi's sarcoma-associated herpesvirus-encoded E3 ubiquitin ligases are determined by the positions of lysine or cysteine residues within the intracytoplasmic domains of their targets. Cadwell K, Coscoy L. J Virol. 2008 Apr;82(8):4184-9. PMID: 18272573

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th. Nature. 2008 Nov 13;456(7219):259-63. PMID: 18849966

The autophagy gene ATG5 plays an essential role in B lymphocyte development.  Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW 4th. Autophagy. 2008 Apr;4(3):309-14. PMID: 18188005

Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado MA, Ponpuak M, Green KG, Schmidt RE, Mizushima N, Deretic V, Sibley LD, Virgin HW. Cell Host Microbe. 2008 Nov 13;4(5):458-69. PMID: 18996346

Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase. Cadwell K, Coscoy L.  Science. 2005 Jul 1;309(5731):127-30. PMID: 15994556